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Chemopreventive effects
of pomegranate seed oil on skin tumor development in CD1
mice.
Hora JJ, Maydew ER, Lansky EP, Dwivedi
C.
Department of Pharmaceutical Sciences, College of
Pharmacy, South Dakota State University, Brookings, SD 57007,
U.S.A.
Pomegranate seed oil was investigated for possible skin
cancer chemopreventive efficacy in mice. In the main experiment, two
groups consisting each of 30, 4-5-week-old, female CD(1) mice were used.
Both groups had skin cancer initiated with an initial topical exposure
of 7,12-dimethylbenzanthracene and with biweekly promotion using
12-O-tetradecanoylphorbol 13-acetate (TPA). The experimental group was
pretreated with 5% pomegranate seed oil prior to each TPA application.
Tumor incidence, the number of mice containing at least one tumor, was
100% and 93%, and multiplicity, the average number of tumors per mouse,
was 20.8 and 16.3 per mouse after 20 weeks of promotion in the control
and pomegranate seed oil-treated groups, respectively (P <.05). In a
second experiment, two groups each consisting of three CD(1) mice were
used to assess the effect of pomegranate seed oil on TPA-stimulated
ornithine decarboxylase (ODC) activity, an important event in skin
cancer promotion. Each group received a single topical application of
TPA, with the experimental group receiving a topical treatment 1 h prior
with 5% pomegranate seed oil. The mice were killed 5 h later, and ODC
activity was assessed by radiometric method. The experimental group
showed a 17% reduction in ODC activity. Pomegrante seed oil (5%)
significantly decreased (P <.05) tumor incidence, multiplicity, and
TPA-induced ODC activity. Overall, the results highlight the potential
of pomegranate seed oil as a safe and effective chemopreventive agent
against skin cancer.
PMID: 14585180 [PubMed - in process]
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